Effect of endosulfan on hematological indices of albino mice

Endosulfan (C₉H₆Cl₆O₃S) belongs to organochlorine group of pesticide, under the cyclodiene subgroup. It used against insects and mites in agriculture and allied sectors. The effects of chemical endosulfan pesticide were investigated on Albino mice. The test was carried out using 1, 2, 3 and 4 mg/kg/d of endosulfan pesticide. Chronic bioassays were evaluated on hematological indices of the Albino mice. Blood sample was collected on weeks 2, 4, 6 and 12 for hematological analysis. There was significant reduction (P<0.05) in red blood cell (RBC) at days 15, 30 and 45, hemoglobin (Hb) at days 15 and 45, and packed cell volume (PCV) at all days of the evaluation. White blood cell (WBC) values however showed significant increase (P<0.05) at days 45 and 60. There were variations in mean values of mean cell volume (MCV), mean cell hemoglobin (MCH) and mean cell hemoglobin