The Biobrio 1(1), 2014

HYPOGLYCEMIC EFFECT AND GENOTOXIC EVALUATION OF LEAF EXTRACT OF CROTON SPARCIFLORUS IN ALLOXAN INDUCED DIABETIC MICE MUS MUSCLES

S. PRAKASH , N. KUMARI , G. P. SINHA , R. RASMITA , K. S. AWASTHY

ABSTRACT:

Oral administration of the methanolic (80%) leaf extract of Croton sparciflorus at the rate of 50 mg (T ), 100mg (T ) and 250mg (T ) per Kg body weight per day for 42 days to alloxan- 1 2 3 induced (150mg/kg bw) diabetic mice Mus muscles significantly (P<0.01) reduced the blood glucose level by 22.0, 33.4, 51.1% at T , 48.7%, 48.9%, 57.2% at T and 49.4%, 54.3%, 1 2 st rd th 57.7% at T ) in the 1 , 3 as 6 week respectively. Considerable fall in elevated blood 3 glucose level was also noted with reference drug Glucobay (10mg/kgbw/day) during the same period of treatment. The genotoxic potential of the leaf extract was also evaluated in the mitotically dividing chromosomes of bone marrow cells which showed no genotoxicity of its own. These results demonstrated that C. sparciflorus is genotoxically safe hypoglycemic agent.

Keywords:    

Alloxan, Hypoglycemia, Glucobay, Genotoxicity

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